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Table 3 Comparative univariate survival analysis the UTUC patients

From: Outcomes of laparoscopic, robotic and open nephroureterectomy with bladder cuff excision in patients with T3T4 upper urinary tract urothelial carcinoma: a multi-center retrospective study

Univariate analysis

OS

CSS

DFS

BRFS

HR (95% CI)

p-value

HR(95% CI)

p-value

HR(95% CI)

p-value

HR(95% CI)

p-value

Group

       

 Open

1

 

1

 

1

 

1

 

 LPS/ HALPS/ LESS

0.552 (0.421, 0.725)

< 0.001**

0.509 (0.372, 0.696)

< 0.001**

0.639 (0.499, 0.818)

< 0.001*

1.008 (0.705, 1.442)

0.963

 Robot

0.496 (0.265, 0.929)

0.029*

0.553 (0.285, 1.075)

0.081

0.808 (0.510, 1.280)

0.364

1.370 (0.748, 2.507)

0.308

Sex

        

 Male

1

 

1

 

1

 

1

 

 Female

1.030 (0.793, 1.337)

0.824

0.974 (0.720, 1.317)

0.865

1.177 (0.932, 1.486)

0.171

0.732 (0.534, 1.003)

0.052

Age

        

 < 70

1

 

1

 

1

 

1

 

 >=70

1.600 (1.228, 2.084)

< 0.001**

1.435 (1.058, 1.945)

0.020*

1.242 (0.984, 1.567)

0.068

1.229 (0.897, 1.685)

0.2

Tumor size

        

 < 2 cm

1

 

1

 

1

 

1

 

 ≥ 2 & < 3 cm

0.729 (0.425, 1.249)

0.249

0.853 (0.438, 1.658)

0.638

1.370 (0.833, 2.254)

0.215

0.673 (0.407, 1.112)

0.122

 ≥ 3cm

1.300 (0.852, 1.982)

0.223

1.669 (0.985, 2.830)

0.057

1.977 (1.289, 3.032)

0.002*

0.635 (0.419, 0.962)

0.032*

Renal pelvis

        

 No

1

 

1

 

1

 

1

 

 Yes

0.768 (0.579, 1.019)

0.067

0.728 (0.527, 1.005)

0.053

0.746 (0.583, 0.955)

0.020*

0.966 (0.684, 1.366)

0.847

Upper ureter

        

 No

1

 

1

 

1

 

1

 

 Yes

0.918 (0.677, 1.244)

0.58

0.962 (0.679, 1.365)

0.83

1.000 (0.765, 1.308)

0.999

1.165 (0.818, 1.658)

0.398

Middle ureter

        

 No

1

 

1

 

1

 

1

 

 Yes

1.208 (0.849, 1.720)

0.293

1.055 (0.690, 1.613)

0.806

1.252 (0.916, 1.712)

0.159

1.238 (0.812, 1.886)

0.321

Lower ureter

        

 No

1

 

1

 

1

 

1

 

 Yes

1.614 (1.194, 2.183)

0.002**

1.692 (1.202, 2.383)

0.003**

1.699 (1.307, 2.207)

< 0.001**

1.724 (1.206, 2.463)

0.003**

Bladder cuff

        

 No

1

 

1

 

1

 

1

 

 Yes

1.794 (1.022, 3.148)

0.042*

1.921 (1.012, 3.644)

0.046*

2.736 (1.648, 4.541)

< 0.001**

2.114 (1.077, 4.149)

0.030*

Laterality

        

 Left

1

 

1

 

1

 

1

 

 Right

1.064 (0.818, 1.383)

0.644

1.042 (0.770, 1.411)

0.788

0.905 (0.717, 1.142)

0.401

0.774 (0.563, 1.064)

0.114

CIS

        

 No

1

 

1

 

1

 

1

 

 Yes

0.929 (0.644, 1.340)

0.693

0.941 (0.619, 1.431)

0.777

0.810 (0.578, 1.135)

0.221

1.292 (0.862, 1.937)

0.215

Multiplicity

        

 No

1

 

1

 

1

 

1

 

 Yes

1.395 (1.071, 1.816)

0.013*

1.392 (1.025, 1.890)

0.034*

1.391 (1.100, 1.760)

0.006**

1.980 (1.443, 2.719)

< 0.001**

Lymphovascular invasion

        

 No

1

 

1

 

1

 

1

 

 Yes

1.275 (0.976, 1.664)

0.075

1.450 (1.069, 1.967)

0.017*

1.555 (1.231, 1.963)

< 0.001**

1.077 (0.777, 1.491)

0.657

Surgical margin

        

 free

1

 

1

 

1

 

1

 

 positive

2.719 (1.837, 4.025)

< 0.001

3.123 (2.038, 4.786)

< 0.001

2.773 (1.942, 3.958)

< 0.001**

0.883 (0.433, 1.800)

0.733

Tumor Necrosis

        

 No

1

 

1

 

1

 

1

 

 Yes

1.306 (0.971, 1.756)

0.077

1.084 (0.758, 1.552)

0.658

1.024 (0.774, 1.355)

0.868

1.064 (0.727, 1.557)

0.75

NUx histology

        

 low grade

1

 

1

 

1

 

1

 

 high grade

2.917 (1.201, 7.086)

0.018

5.450 (1.351, 21.990)

0.017

6.365 (2.039, 19.867)

0.001

0.743 (0.412, 1.340)

0.323

Synchronous bladder tumor

        

 No

1

 

1

 

1

 

1

 

 Previous Hx of bladder UC

1.417 (0.834, 2.409)

0.197

1.326 (0.715, 2.460)

0.37

0.903 (0.526, 1.551)

0.713

2.691 (1.562, 4.637)

< 0.001**

 Concurrent Bladder UC

1.624 (1.160, 2.272)

0.005**

1.606 (1.088, 2.370)

0.017*

1.521 (1.126, 2.055)

0.006**

2.899 (2.011, 4.180)

< 0.001**

NxUx access

        

 Transperitoneal

1

 

1

 

1

 

1

 

 Retroperitoneal

1.483 (1.122, 1.960)

0.006**

1.526 (1.105, 2.108)

0.010*

1.229 (0.966, 1.564)

0.093

0.837 (0.605, 1.157)

0.281

Harvested LN number

        

 < 4

1

 

1

 

1

 

1

 

 >= 4

0.667 (0.402, 1.108)

0.118

0.630 (0.358, 1.109)

0.109

0.935 (0.614, 1.422)

0.752

0.726 (0.386, 1.366)

0.321

Post operation intravesical C/T instillation

        

 No

1

 

1

 

1

 

1

 

 Yes

1.647 (1.014, 2.677)

0.044*

1.743 (1.023, 2.972)

0.041*

1.756 (1.171, 2.635)

0.007**

1.931 (1.110, 3.360)

0.020*

Pathological stage T

        

 pT3

1

 

1

 

1

 

1

 

 pT4

2.798 (2.031, 3.854)

< 0.001**

3.179 (2.226, 4.540)

< 0.001**

2.497 (1.855, 3.363)

< 0.001**

0.345 (0.153, 0.780)

0.011*

Pathological stage N

        

 pN0

1

 

1

 

1

 

1

 

 pN1

2.291 (1.209, 4.342)

0.011*

2.689 (1.358, 5.326)

0.005**

2.477 (1.372, 4.472)

0.003**

1.425 (0.596, 3.409)

0.426

 pN2

1.615 (0.834, 3.127)

0.156

2.106 (1.064, 4.168)

0.033*

3.068 (1.847, 5.096)

< 0.001**

0.539 (0.165, 1.761)

0.306

 pNx

1.148 (0.821, 1.604)

0.42

1.118 (0.758, 1.649)

0.574

1.261 (0.928, 1.713)

0.138

1.237 (0.836, 1.830)

0.288

DM

        

 No

1

 

1

 

1

 

1

 

 Yes

1.427 (1.068, 1.908)

0.016*

1.275 (0.903, 1.799)

0.167

1.127 (0.859, 1.478)

0.389

1.396 (0.977, 1.997)

0.067

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