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Table 4 Comparative multivariable survival analysis

From: Outcomes of laparoscopic, robotic and open nephroureterectomy with bladder cuff excision in patients with T3T4 upper urinary tract urothelial carcinoma: a multi-center retrospective study

Multivariable analysis

OS

Multivariable analysis

OS

 

HR (95% CI)

p-value

HR (95% CI)

p-value

Age

  

NxUx access

  

 < 70

1

 

Transperitoneal

1

 

 >=70

1.721 (1.247, 2.375)

0.001*

Retroperitoneal

1.698 (1.212, 2.379)

0.002*

Lower ureter

  

Post operation intravesical C/T instillation

  

 No

1

 

No

1

 

 Yes

1.213 (0.827, 1.780)

0.323

Yes

1.716 (0.997, 2.952)

0.051

Bladder cuff

  

Pathological stage T

  

 No

1

 

pT3

1

 

 Yes

1.154 (0.569, 2.340)

0.691

pT4

2.785 (1.811, 4.284)

< 0.001*

Multiplicity

  

Pathological stage N

  

 No

1

 

pN0

1

 

 Yes

1.328 (0.965, 1.827)

0.082

pN1

2.560 (1.288, 5.089)

0.007*

Surgical margin

  

pN2

0.707 (0.299, 1.672)

0.429

 Free

1

 

pNx

0.785 (0.529, 1.166)

0.231

 Positive

1.597 (0.921, 2.769)

0.096

HTN

  

NUx histology

  

No

1

 

 low grade

1

 

Yes

1.119 (0.815, 1.537)

0.487

 high grade

2.158 (0.872, 5.345)

0.096

DM

  

Synchronous bladder tumor

  

No

1

 

 No

1

 

Yes

1.900 (1.346, 2.681)

< 0.001*

 Previous Hx of bladder UC

1.491 (0.820, 2.711)

0.191

Perioperative chemotherapy

  

 Concurrent Bladder UC

1.230 (0.820, 1.844)

0.317

No

1

 

Residual bladder cuff

  

Yes

0.599(0.414, 0.866)

0.006*

 No

1

    

 Yes

1.219(0.733, 2.027)

0.445

   

Group

  

NUx histology

  

 Open

1

 

low grade

1

 

 LPS/ HALPS/ LESS

0.465 (0.323, 0.670)

< 0.001*

high grade

3.809 (0.932, 15.566)

0.063

 Robot

0.585 (0.249, 1.373)

0.218

Synchronous bladder tumor

  

Age

  

No

1

 

 < 70

1

 

Previous Hx of bladder UC

1.322 (0.677, 2.582)

0.414

 >=70

1.563 (1.094, 2.232)

0.014*

Concurrent Bladder UC

1.287 (0.823, 2.013)

0.269

Lower ureter

  

NxUx access

  

 No

1

 

Transperitoneal

1

 

 Yes

1.225 (0.801, 1.873)

0.349

Retroperitoneal

1.571 (1.076, 2.293)

0.019*

Bladder cuff

  

Post operation intravesical C/T instillation

  

 No

1

 

No

1

 

 Yes

1.028 (0.462, 2.290)

0.946

Yes

1.754 (0.970, 3.175)

0.063

Multiplicity

  

Pathological stage T

  

 No

1

 

pT3

1

 

 Yes

1.322 (0.921, 1.897)

0.13

pT4

2.515 (1.563, 4.045)

< 0.001*

Lymphovascular invasion

  

Pathological stage N

  

 No

1

 

pN0

1

 

 Yes

1.315 (0.930, 1.861)

0.122

pN1

2.557 (1.227, 5.330)

0.012*

Surgical margin

  

pN2

0.912 (0.383, 2.175)

0.836

 Free

1

 

pNx

0.836 (0.538, 1.299)

0.426

 Positive

1.563 (0.845, 2.892)

0.155

   

Group

  

Surgical margin

  

 Open

1

 

Free

1

 

 LPS/ HALPS/ LESS

0.787 (0.564, 1.099)

0.16

Positive

2.007 (1.260, 3.197)

0.003*

 Robot

0.969 (0.540, 1.739)

0.917

NUx histology

  

Tumor size

  

low grade

1

 

 < 2 cm

1

 

high grade

5.924 (1.459, 24.054)

0.013*

 ≥ 2 & < 3 cm

1.627 (0.953, 2.775)

0.074

Synchronous bladder tumor

  

 ≥ 3cm

1.984 (1.244, 3.167)

0.004*

No

1

 

Renal pelvis

  

Previous Hx of bladder UC

1.027 (0.563, 1.872)

0.931

 No

1

 

Concurrent Bladder UC

1.169 (0.802, 1.706)

0.416

 Yes

0.728 (0.506, 1.048)

0.088

Post operation intravesical C/T instillation

  

Lower ureter

  

No

1

 

 No

1

 

Yes

1.813 (1.109, 2.963)

0.018*

 Yes

1.200 (0.837, 1.721)

0.32

Pathological stage T

  

Bladder cuff

  

pT3

1

 

 No

1

 

pT4

1.555 (1.003, 2.411)

0.048*

 Yes

1.465 (0.790, 2.717)

0.226

Pathological stage N

  

Multiplicity

  

pN0

1

 

 No

1

 

pN1

2.407 (1.282, 4.518)

0.006*

 Yes

1.366 (0.997, 1.872)

0.052

pN2

1.814 (0.985, 3.343)

0.056

Lymphovascular invasion

  

pNx

1.117 (0.797, 1.567)

0.519

 No

1

 

Perioperative chemotherapy

  

 Yes

1.317 (0.988, 1.756)

0.06

No

1

 
   

Yes

0.456(0.324, 0.642)

< 0.001

Group

  

Pathological stage T

  

 Open

1

 

pT3

1

 

 LPS/ HALPS/ LESS

0.888 (0.546, 1.443)

0.632

pT4

0.127 (0.030, 0.529)

0.005*

 Robot

1.017 (0.478, 2.164)

0.965

Perioperative chemotherapy

  

Tumor size

  

No

1

 

 < 2 cm

1

 

Yes

0.552 (0.366, 0.832)

0.005*

 ≥ 2 & < 3 cm

0.842 (0.484, 1.466)

0.544

   

 ≥ 3cm

0.827 (0.519, 1.317)

0.424

   

Lower ureter

     

 No

1

    

 Yes

1.267 (0.804, 1.997)

0.307

   

Bladder cuff

     

 No

1

    

 Yes

1.376 (0.597, 3.174)

0.454

   

Multiplicity

     

 No

1

    

 Yes

1.438 (0.961, 2.153)

0.077

   

Synchronous bladder tumor

     

 No

1

    

 Previous Hx of bladder UC

2.338 (1.243, 4.395)

0.008

   

 Concurrent Bladder UC

2.408 (1.507, 3.849)

< 0.001*

   

Post operation intravesical C/T instillation

     

 No

1

    

 Yes

1.455 (0.786, 2.693)

0.233

   
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BMC Urology

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